ML311
产品说明书
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同义名 : | - |
| CAS号 : | 315698-17-0 | |
| 货号 : | A1142868 | |
| 分子式 : | C23H24F3N3O | |
| 纯度 : | 98%+ | |
| 分子量 : | 415.451 | |
| MDL号 : | MFCD02330695 | |
| 存储条件： |
Pure form Sealed in dry,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 65 mg/mL(156.46 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | ML311 effectively halts the viability of several Mcl-1 dependent cell types, including MCL-1-1780 (EC50=0.31 μM), DHL-6 (EC50=3.3 μM), and NCI-H929 (EC50=1.6 μM), typically with high maximal effects (>80%). ML311 also shows activity in leukemia-derived cell lines that are particularly reliant on Bcl-2 function (Bcl2-1863, EC50=1.1 μM). ML311 exhibits strong growth inhibitory effects across multiple cell lines, with GI50 values less than 900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3), and less than 2 μM for an additional 14 types of cell line[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.41mL 0.48mL 0.24mL |
12.04mL 2.41mL 1.20mL |
24.07mL 4.81mL 2.41mL |
| 参考文献 |
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