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Isoconazole nitrate

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Chemical Structure| 24168-96-5 同义名 : Isoconazole (nitrate);R 15454;Adestan G 100
CAS号 : 24168-96-5
货号 : A113906
分子式 : C18H15Cl4N3O4
纯度 : 98%
分子量 : 479.141
MDL号 : MFCD01721647
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(219.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Isoconazole nitrate (ISN) is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, a rapid rate of absorption and low systemic exposure potential. ISN is effective against pathogens involved in dermatomycoses, with minimum inhibitory concentrations well below the concentration of ISN in skin and hair follicles[3]. Treatment results with the combination of isoconazole nitrate and diflucortolone valerate were superior regarding erythema and pruritus[4]. 1% isoconazole nitrat is more effective than a commercial cream containing 1% clotrimazole[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00722189 - Completed - Russian Federation ... 展开 >> Kashkin Clinical Research Mycological Institute St Petersburg, Russian Federation 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.09mL

0.42mL

0.21mL

10.44mL

2.09mL

1.04mL

20.87mL

4.17mL

2.09mL
参考文献

[1]Bianchi L, Hansel K, et al. Contact allergy to isoconazole nitrate with unusual spreading over extensive regions. Contact Dermatitis. 2017 Apr;76(4):243-245.

[2]Czaika VA, Siebenbrock J, et al. Reactive oxygen species and the bacteriostatic and bactericidal effects of isoconazole nitrate. Mycoses. 2013 May;56 Suppl 1:16-22.

[3]Veraldi S. Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids. Mycoses. 2013;56 Suppl 1:3–15.

[4]Veraldi S, Persico MC, Schianchi R. Isoconazole nitrate vs isoconazole nitrate and diflucortolone valerate in the treatment of tinea inguinalis: results of a multicenter retrospective study. J Drugs Dermatol. 2012;11(11):e70–e73.

[5]Wendt H, Kessler J. Antimikrobielle Wirksamkeit des Breitspektrum-Antimykotikums Isoconazolnitrat im Humanversuch [Antimicrobial activity of the broad spectrum antimycotic isoconazole nitrate in humans (author's transl)]. Arzneimittelforschung. 1979;29(5):846–848.