Isoconazole nitrate
产品说明书
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同义名 : | Isoconazole (nitrate);R 15454;Adestan G 100 |
| CAS号 : | 24168-96-5 | |
| 货号 : | A113906 | |
| 分子式 : | C18H15Cl4N3O4 | |
| 纯度 : | 98% | |
| 分子量 : | 479.141 | |
| MDL号 : | MFCD01721647 | |
| 存储条件： |
Pure form Sealed in dry,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(219.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Isoconazole nitrate (ISN) is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, a rapid rate of absorption and low systemic exposure potential. ISN is effective against pathogens involved in dermatomycoses, with minimum inhibitory concentrations well below the concentration of ISN in skin and hair follicles[3]. Treatment results with the combination of isoconazole nitrate and diflucortolone valerate were superior regarding erythema and pruritus[4]. 1% isoconazole nitrat is more effective than a commercial cream containing 1% clotrimazole[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00722189 | - | Completed | - | Russian Federation ... 展开 >> Kashkin Clinical Research Mycological Institute St Petersburg, Russian Federation 收起 << | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.09mL 0.42mL 0.21mL |
10.44mL 2.09mL 1.04mL |
20.87mL 4.17mL 2.09mL |
| 参考文献 |
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