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Chicoric acid

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Chemical Structure| 6537-80-0 同义名 : Dicaffeoyltartaric acid;Cichoric Acid
CAS号 : 6537-80-0
货号 : A111607
分子式 : C22H18O12
纯度 : 99%+
分子量 : 474.371
MDL号 : MFCD00189418
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 1 mg/mL(2.11 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(210.81 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Cichoric acid (CA), a polyphenol component from Echinacea purpurea, exhibits preventive effects on liver lipid-metabolism disorders in obesity. CA (200 μM) regulated the circadian rhythm expressions of clock genes and the relatively shallow daily oscillations. CA has a Bmal1 resistance to lipid accumulation by enhancing the Akt/GSK3β signaling pathways and modulating the downstream expressions related to lipid metabolism[3]. CA inhibited pancreas apoptosis and adjusted islet function in diabetic mice, leading to an increase in insulin generation and secretion. Moreover, CA regulated mitochondrial biogenesis, glycogen synthesis, and inhibited inflammation via activating antioxidant responses, which contributes to the improvement in athletic ability and diabetic myopathy[4]. Furthermore, CA was verified to promote glucosamine-mediated glucose uptake and inhibited inflammation through PI3K/Akt, NF-κB, and MAPK signaling pathways in HepG2 cells[5]. CA exhibits cytoprotective activity against DOX-induced (Doxorubicin) damage by lowering oxidative stress level and by inhibiting apoptosis[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00065715 Common Cold Phase 3 Completed - United States, Wisconsin ... 展开 >> University of Wisconsin-Madison Department of Family Medicine Madison, Wisconsin, United States, 53706-1490 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.11mL

0.42mL

0.21mL

10.54mL

2.11mL

1.05mL

21.08mL

4.22mL

2.11mL
参考文献

[1]Zhu D, Zhang X, et al. Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice. Food Chem Toxicol. 2017 Sep;107(Pt A):138-149.

[2]Chen L, Huang G, et al. Chicoric acid suppresses BAFF expression in B lymphocytes by inhibiting NF-κB activity. Int Immunopharmacol. 2017 Mar;44:211-215.

[3]Guo R, Zhao B, Wang Y, et al. Cichoric Acid Prevents Free-Fatty-Acid-Induced Lipid Metabolism Disorders via Regulating Bmal1 in HepG2 Cells. J Agric Food Chem. 2018;66(37):9667-9678

[4]Zhu D, Zhang X, Niu Y, et al. Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice. Food Chem Toxicol. 2017;107(Pt A):138-149

[5]Zhu D, Wang Y, Du Q, Liu Z, Liu X. Cichoric Acid Reverses Insulin Resistance and Suppresses Inflammatory Responses in the Glucosamine-Induced HepG2 Cells. J Agric Food Chem. 2015;63(51):10903-10913

[6]Jabłońska-Trypuć A, Krętowski R, Kalinowska M, Świderski G, Cechowska-Pasko M, Lewandowski W. Possible Mechanisms of the Prevention of Doxorubicin Toxicity by Cichoric Acid-Antioxidant Nutrient. Nutrients. 2018;10(1):44. Published 2018 Jan 5