H-D-Ser-OH
产品说明书
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同义名 : | (R)-Serine;NSC 77689 |
| CAS号 : | 312-84-5 | |
| 货号 : | A111308 | |
| 分子式 : | C3H7NO3 | |
| 纯度 : | 95% | |
| 分子量 : | 105.093 | |
| MDL号 : | MFCD00004269 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,Room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
H2O: 50 mg/mL(475.77 mM) |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | D-Serine, also known as (R)-Serine, is a naturally occurring amino acid that plays a crucial role in the interaction between glial cells and synapses, exhibiting distinctive neurotransmitter properties. It serves as an effective co-agonist for the NMDA glutamate receptor. D-Serine is fundamentally involved in several NMDAR-related functions, such as NMDAR-driven neurotransmission, neurotoxicity, synaptic plasticity, and cellular migration[1][2]. (R)-Serine is produced from L-Serine through the action of serine racemase and is broken down by both DAAO and serine racemase. The presence of D-Serine and NMDAR, as confirmed by chemical analysis and immunohistochemical methods, endorses the role of D-Serine as a natural co-agonist at the glycine-binding site on the NR1 subunit of NMDARs[3]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
9.52mL 1.90mL 0.95mL |
47.58mL 9.52mL 4.76mL |
95.15mL 19.03mL 9.52mL |
| 参考文献 |
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[1]Andrea R. Durrant, et al. D-Serine in Neuropsychiatric Disorders: New Advances. |