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GW 441756

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Chemical Structure| 504433-23-2 同义名 : -
CAS号 : 504433-23-2
货号 : A110513
分子式 : C17H13N3O
纯度 : 99%+
分子量 : 275.305
MDL号 : MFCD17010281
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 16 mg/mL(58.12 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 GW 441756 is identified as a highly effective and selective inhibitor for the nerve growth factor (NGF) receptor tyrosine kinases A (TrkA), displaying an IC50 of 2 nM. This specificity allows it to effectively neutralize BmK NSPK-induced neurite outgrowth[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.63mL

0.73mL

0.36mL

18.16mL

3.63mL

1.82mL

36.32mL

7.26mL

3.63mL
参考文献

[1]Zhao F, et al. BmK NSPK, a Potent Potassium Channel Inhibitor from Scorpion Buthus martensii Karsch, Promotes Neurite Outgrowth via NGF/TrkA Signaling Pathway. Toxins (Basel). 2021;13(1):33. Published 2021 Jan 5.

[2]Terada K, et al. Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors. PLoS One. 2018;13(12):e0209250. Published 2018 Dec 17.

[3]Wood ER, et al. Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg Med Chem Lett. 2004;14(4):953-957.