Nitrofurantoin
产品说明书
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同义名 : | NSC 2107;Macrodantin;Nitrofurantoin, Macrobid, Macrodantin, 5-Nitrofurantoin, Furadantine, Furadonine;NSC 44150;Furadonine;Furadantine |
| CAS号 : | 67-20-9 | |
| 货号 : | A109585 | |
| 分子式 : | C8H6N4O5 | |
| 纯度 : | 98+% | |
| 分子量 : | 238.157 | |
| MDL号 : | MFCD00003224 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,Room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(440.89 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Nitrofurantoin is an old antibiotic and an important first-line oral antibiotic for the treatment of uncomplicated urinary tract infections. Nitrofurantoin is not a uniform product -crystal sizes of nitrofurantoin, and therefore pharmacokinetic properties, differ significantly by product[3]. A broad spectrum of liver toxicity associated with nitrofurantoin use has been reported, ranging from acute hepatitis, granulomatous reaction, cholestasis, or autoimmune-mediated hepatitis to chronic active hepatitis that could lead to cirrhosis or death[4]. On the basis of urinary nitrofurantoin excretion determined after oral and intravenous drug administration, orally administered nitrofurantoin in a suitable dosage form is well absorbed[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03466502 | Clostridium Difficile Infectio... 展开 >>n 收起 << | Phase 4 | Enrolling by invitation | March 2019 | United States, Nevada ... 展开 >> Renown Regional Medical Center Reno, Nevada, United States, 89502 收起 << |
| NCT01349738 | - | Unknown | May 2013 | United States, California ... 展开 >> Scripps Green Hospital La Jolla, California, United States, 92037 收起 << | |
| NCT03508921 | Overactive Bladder ... 展开 >> Urinary Tract Infections 收起 << | Phase 4 | Recruiting | September 1, 2019 | United States, Tennessee ... 展开 >> Vanderbilt University Medical Center Recruiting Nashville, Tennessee, United States, 37232 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.20mL 0.84mL 0.42mL |
20.99mL 4.20mL 2.10mL |
41.99mL 8.40mL 4.20mL |
| 参考文献 |
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