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Piperonyl butoxide

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Chemical Structure| 51-03-6 同义名 : 胡椒基丁醚 ;ENT-14250;NSC 8401
CAS号 : 51-03-6
货号 : A108763
分子式 : C19H30O5
纯度 : 95+%
分子量 : 338.438
MDL号 : MFCD00005842
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(310.25 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 100 mg/mL(295.47 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
描述 Piperonyl butoxide is a semi-synthetic synergist for natural pyrethrum and synthetic pyrethroid insecticides in phytochemicals and biocides. Piperonyl butoxide is consequently a regular contaminant in stored grains, and subsequently in corresponding cereal food products and meat via feed uses[3]. Regarding multiple-T water maze performance at 10 weeks of age, no significant effect caused by PBO (Piperonyl Butoxide) treatment was observed. Exploratory behaviour examination of 8-week-old female mice indicated that the average speed declined in a significant dose-related manner, and the longitudinal pattern indicated a significant difference between the control and high-dose groups. For exploratory behaviour examination at 11 weeks of age, the total exploration distance shortened in a significant dose-related manner, and the average speed declined similarly. The PBO dose levels in this study produced several adverse effects on exploratory behaviour in female mice[4]. In addition, piperonyl butoxide activated c-Jun and ATF-2 in mouse hepatocytes during the early stage of hepatocarcinogenesis[5]. The inclusion of PBO along with emamectin significantly reduced resistant field populations of T. castaneum by at least 28% and the LC50 were lowered from 5.12 to 1.9 μg/ml with the highest synergism ration of 2.7 in resistant strain[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.30mL

14.77mL

2.95mL

1.48mL

29.55mL

5.91mL

2.95mL
参考文献

[1]Vardavas AI, Fragkiadaki P, et al. Downgrading the systemic condition of rabbits after long term exposure to cypermethrin and piperonyl butoxide. Life Sci. 2016 Jan 15;145:114-20.

[2]Pereira BB, Limongi JE, et al. Effects of piperonyl butoxide on the toxicity of the organophosphate temephos and the role of esterases in the insecticide resistance of Aedes aegypti. Rev Soc Bras Med Trop. 2014 Sep-Oct;47(5):579-82.

[3]Marchand PA, Dimier-Vallet C, Vidal R. Biorational substitution of piperonyl butoxide in organic production: effectiveness of vegetable oils as synergists for pyrethrums. Environ Sci Pollut Res Int. 2018;25(30):29936‐29942

[4]Tanaka T, Suzuki T, Inomata A. Effects of piperonyl butoxide on exploratory behaviour in female mice. Toxicol Ind Health. 2019;35(4):314‐323

[5]Muguruma M, Arai K, Moto M, Nishimura J, Dewa Y, Mitsumori K. Piperonyl butoxide activates c-Jun and ATF-2 in the hepatocytes of mice. Arch Toxicol. 2008;82(10):749‐753

[6]Awan DA, Ahmad F, Saleem MA, Shakoori AR. Synergistic effect of piperonyl butoxide and emamectin benzoate on enzymatic activities in resistant populations of red flour beetle, Tribolium castaneum Herbst (Coleoptera: Tenebrionidae). Environ Sci Pollut Res Int. 2019;26(14):14200‐14213