6-TAMRA

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Chemical Structure| 91809-67-5 同义名 : 6-Carboxytetramethylrhodamine
CAS号 : 91809-67-5
货号 : A108064
分子式 : C25H22N2O5
纯度 : 99%+
分子量 : 430.45
MDL号 : MFCD29477680
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 2 mg/mL(4.65 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

PO 0.5% CMC-Na 40 mg/mL suspension

生物活性
描述 6-TAMRA has been a widely used fluorophore for preparing bioconjugates, especially fluorescent antibody and avidin derivatives used in immunochemistry. The CPPs (Cell-penetrating peptides) facilitated permeation of the paracellular flux marker mannitol as well as the transcellular flux marker propranolol. The peptides were labelled with the fluorophore 6-TAMRA (T) for visualization and quantification purposes[1]. Dendrimer nanoparticles targeted by folic acid and having 6-TAMRA as a fluorescent probe were also used to label KB cell tumors in vivo[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.32mL

0.46mL

0.23mL

11.62mL

2.32mL

1.16mL

23.23mL

4.65mL

2.32mL
参考文献

[1]Frøslev P, Franzyk H, Ozgür B, Brodin B, Kristensen M. Highly cationic cell-penetrating peptides affect the barrier integrity and facilitates mannitol permeation in a human stem cell-based blood-brain barrier model. Eur J Pharm Sci. 2022 Jan 1;168:106054

[2]Thomas TP, Myaing MT, Ye JY, Candido K, Kotlyar A, Beals J, Cao P, Keszler B, Patri AK, Norris TB, Baker JR Jr. Detection and analysis of tumor fluorescence using a two-photon optical fiber probe. Biophys J. 2004 Jun;86(6):3959-65