Tovorafenib

产品说明书

Print
Chemical Structure| 1096708-71-2 同义名 : TAK-580;MLN2480;BUB 024;DAY-101;BSK1369;AMG-2112819;BIIB-024
CAS号 : 1096708-71-2
货号 : A107516
分子式 : C17H12Cl2F3N7O2S
纯度 : 99%+
分子量 : 506.289
MDL号 : MFCD22571730
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(207.39 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Raf
描述 Tovorafenib (TAK-580, MLN 2480) acts by counteracting the feedback activation of MEK triggered by TAK-733, resulting in more coordinated inhibition of the MAPK pathway [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.98mL

0.40mL

0.20mL

9.88mL

1.98mL

0.99mL

19.75mL

3.95mL

1.98mL
参考文献

[1]Elizabeth Grace Carideo Cunniff, et al. Abstract C146: Combination treatment with the investigational RAF kinase inhibitor MLN2480 and the investigational MEK kinase inhibitor TAK-733 inhibits the growth of BRAF mutant and RAS mutant preclinical models of