Laurocapram
产品说明书
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同义名 : | 氮酮;月桂氮卓酮;1-十二烷基氮杂环庚烷-2-酮 |
| CAS号 : | 59227-89-3 | |
| 货号 : | A107258 | |
| 分子式 : | C18H35NO | |
| 纯度 : | 97% | |
| 分子量 : | 281.477 | |
| MDL号 : | MFCD00190580 | |
| 存储条件： |
Pure form Sealed in dry,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(373.03 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Laurocapram, named as azone, is a new percutaneous penetration enhancer[1]. In vitro studies, laurocapram could decrease skin permeation of celecoxib (CXB) and locate CXB in stratum corneum (SC), epidermis and dermis, while have not cytotoxicity or genotoxicity[2]. Besides this, it was found that laurocapram could slowly release diazepam in buccal mucosa[3]. In vivo studies, laurocapram has the ability of enhancing the transdermal absorption in mouse skin, through drilling the holes on the biomembrane and enlarging the orifice of hair follicles[1]. In addition, laurocapram could contribute to the mild skin irritation and the inhibition of ear edema[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.55mL 0.71mL 0.36mL |
17.76mL 3.55mL 1.78mL |
35.53mL 7.11mL 3.55mL |
| 参考文献 |
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