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Troxerutin

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Chemical Structure| 7085-55-4 同义名 : 维脑路通 ;Trihydroxyethylrutin;Vitamin P4;Z 6000;Venoruton P4;L Venoruton;Veno S;Venaroid;Veinamitol Pulver;Pherarutin;Helveton;Flebil;Factor P-zyma
CAS号 : 7085-55-4
货号 : A105819
分子式 : C33H42O19
纯度 : 97+%
分子量 : 742.675
MDL号 : MFCD00893813
存储条件:

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(141.38 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(67.32 mM)

动物实验配方:
生物活性
描述 Troxerutin, is natural flavonoid rutin present in tea, coffee, cereal grains and a variety of fruits and vegetables. It can improve capillary function, reduce capillary fragility and abnormal leakage. Toxerutin preconditioning significantly reduced myocardial infarct size, improved cardiac function[3].In addition, troxerutin protects against cardiomyopathy via alterations in NF-κB, AKT and IRS1 signaling, in a rat model of type 2 diabetes[4].And troxerutin regulated the inflammatory lesions via CXCR4-TXNIP/NLRP3(C-X-C chemokine ligand 12 receptor 4-thioredoxin interaction protein) inflammasome in the kidney of mice induced by BDE-47(2,2',4,4'-Tetrabromodiphenyl ether)[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.35mL

0.27mL

0.13mL

6.73mL

1.35mL

0.67mL

13.46mL

2.69mL

1.35mL

参考文献

[1]Boisseau MR, Taccoen A, et al. Fibrinolysis and hemorheology in chronic venous insufficiency: a double blind study of troxerutin efficiency. J Cardiovasc Surg (Torino). 1995 Aug;36(4):369-74.

[2]Olszewski AJ, Szostak WB, et al. Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis. Atherosclerosis. 1989 Jan;75(1):1-6. Erratum in: Atherosclerosis 1991 May;88(1):978.

[3]Shu L, Zhang W, Huang C, Huang G, Su G. Troxerutin Protects Against Myocardial Ischemia/Reperfusion Injury Via Pi3k/Akt Pathway in Rats. Cell Physiol Biochem. 2017;44(5):1939-1948. doi: 10.1159/000485884. Epub 2017 Dec 8. PMID: 29241161.

[4]Yu Y, Zheng G. Troxerutin protects against diabetic cardiomyopathy through NF‑κB/AKT/IRS1 in a rat model of type 2 diabetes. Mol Med Rep. 2017 Jun;15(6):3473-3478. doi: 10.3892/mmr.2017.6456. Epub 2017 Apr 11. PMID: 28440404; PMCID: PMC5436284.

[5]Shan Q, Zheng GH, Han XR, Wen X, Wang S, Li MQ, Zhuang J, Zhang ZF, Hu B, Zhang Y, Zheng YL. Troxerutin Protects Kidney Tissue against BDE-47-Induced Inflammatory Damage through CXCR4-TXNIP/NLRP3 Signaling. Oxid Med Cell Longev. 2018 Apr 19;2018:9865495. doi: 10.1155/2018/9865495. PMID: 29849929; PMCID: PMC5932985.