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Ginsenoside Rg1

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Chemical Structure| 22427-39-0 同义名 : 人参皂甙 Rg1 ;Panaxoside Rg1;Panaxoside A;Sanchinoside Rg1;Sanchinoside C1;Ginsenoside A2
CAS号 : 22427-39-0
货号 : A100956
分子式 : C42H72O14
纯度 : 98%
分子量 : 801.013
MDL号 : MFCD00210293
存储条件:

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(131.08 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 10 mg/mL(12.48 mM),配合低频超声助溶

动物实验配方:
生物活性
描述 Ginsenoside Rg1, one of the most notable active components of Panax ginseng, has anti-inflammatory actions. In vitro, ginsenoside Rg1 functioned to HK-2 cells in a dose-dependent manner, and the 150 μM dose exhibited the most protective functions. Ginsenoside Rg1 protects HK-2 cells against LPS-induced inflammation and apoptosis[3]. Moreover, ginsenoside Rg1 alleviates CS-induced pulmonary EMT in both COPD rats and HBE cells[4]. In vivo, Ginsenoside Rg1 treatment (10 mg/mL) lameliorated depression-like behaviors and reduced chronic unpredictable mild stress exposure-Induced microglial activation and inflammatory cytokine expression within the ventral medial prefrontal cortex[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.25mL

0.25mL

0.12mL

6.24mL

1.25mL

0.62mL

12.48mL

2.50mL

1.25mL

参考文献

[1]He J, Li YL. Ginsenoside Rg1 downregulates the shear stress induced MCP-1 expression by inhibiting MAPK signaling pathway. Am J Chin Med. 2015;43(2):305-17.

[2]Liu QF, Deng ZY, et al. Ginsenoside Rg1 protects chronic cyclosporin a nephropathy from tubular cell apoptosis by inhibiting endoplasmic reticulum stress in rats. Transplant Proc. 2015 Mar;47(2):566-9.

[3]Ni XJ, Xu ZQ, Jin H, Zheng SL, Cai Y, Wang JJ. Ginsenoside Rg1 protects human renal tubular epithelial cells from lipopolysaccharide-induced apoptosis and inflammation damage. Braz J Med Biol Res. 2017 Dec 11;51(2):e6611. doi: 10.1590/1414-431X20176611. Retraction in: Braz J Med Biol Res. 2020;53(10):e6611retraction. PMID: 29267498; PMCID: PMC5731327.

[4]Guan S, Xu W, Han F, Gu W, Song L, Ye W, Liu Q, Guo X. Ginsenoside Rg1 Attenuates Cigarette Smoke-Induced Pulmonary Epithelial-Mesenchymal Transition via Inhibition of the TGF-β1/Smad Pathway. Biomed Res Int. 2017;2017:7171404. doi: 10.1155/2017/7171404. Epub 2017 Aug 13. PMID: 29104873; PMCID: PMC5572594.

[5]Fan C, Song Q, Wang P, Li Y, Yang M, Yu SY. Neuroprotective Effects of Ginsenoside-Rg1 Against Depression-Like Behaviors via Suppressing Glial Activation, Synaptic Deficits, and Neuronal Apoptosis in Rats. Front Immunol. 2018 Dec 7;9:2889. doi: 10.3389/fimmu.2018.02889. PMID: 30581440; PMCID: PMC6292928.