产品说明书

Fedovapagon

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Chemical Structure| 347887-36-9 同义名 : VA106483
CAS号 : 347887-36-9
货号 : A1005817
分子式 : C27H34N4O3
纯度 : 97%
分子量 : 462.584
MDL号 : MFCD19443737
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(259.41 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Fedovapagon (VA106483) is a vasopressin V2 receptor (V2R) agonist that is both selective and orally active, with an EC50 of 24 nM. Its utility extends to research on nocturia[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.16mL

0.43mL

0.22mL

10.81mL

2.16mL

1.08mL

21.62mL

4.32mL

2.16mL
参考文献

[1]Yea CM, et al. New benzylureas as a novel series of potent, nonpeptidic vasopressin V2 receptor agonists. J Med Chem. 2008 Dec 25;51(24):8124-34.

[2]Pang Y, et al. In Vitro Activity of Bedaquiline against Nontuberculous Mycobacteria in China. Antimicrob Agents Chemother. 2017 Apr 24;61(5).