产品说明书

Phortress

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Chemical Structure| 328087-38-3 同义名 : NSC 710305
CAS号 : 328087-38-3
货号 : A1000372
分子式 : C20H25Cl2FN4OS
纯度 : 97%
分子量 : 459.408
MDL号 : MFCD06407804
存储条件:

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 120 mg/mL(261.21 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Phortress is a high-affinity AhR ligand that stimulates antitumour activity by inducing CYP1A1 transcription [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.18mL

0.44mL

0.22mL

10.88mL

2.18mL

1.09mL

21.77mL

4.35mL

2.18mL

参考文献

[1]Bradshaw TD, et al. In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles. Br J Cancer. 2002 Apr 22;86(8):1348-54.

[2]Bradshaw TD, Westwell AD. The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate. Curr Med Chem. 2004 Apr;11(8):1009-21.