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D609

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Chemical Structure| 83373-60-8 同义名 : Tricyclodecan-9-yl xanthogenate;D609 (potassium salt);D-609 free
CAS号 : 83373-60-8
货号 : A997327
分子式 : C11H15KOS2
纯度 : 98+%
分子量 : 266.464
MDL号 : MFCD00171401
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(394.05 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2 mg/mL(7.51 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM) and antiviral and antitumor agent.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00669734 Pancreatic Acinar Cell Carcino... 展开 >>ma Pancreatic Ductal Adenocarcinoma Stage III Pancreatic Cancer AJCC v6 and v7 Stage IV Pancreatic Cancer AJCC v6 and v7 收起 << Phase 1 Active, not recruiting - United States, New Jersey ... 展开 >> Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.75mL

0.75mL

0.38mL

18.76mL

3.75mL

1.88mL

37.53mL

7.51mL

3.75mL
参考文献

[1]Zhou D, Lauderback CM, et al. D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant. J Pharmacol Exp Ther. 2001 Jul;298(1):103-9.

[2]Amtmann E. The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs Exp Clin Res. 1996;22(6):287-94.