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Fiboflapon

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Chemical Structure| 936350-00-4 同义名 : Gsk2190915;AM-803
CAS号 : 936350-00-4
货号 : A996325
分子式 : C38H43N3O4S
纯度 : 98%
分子量 : 637.831
MDL号 : MFCD18633268
存储条件：

粉末

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(78.39 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 GSK2190915 is a potent FLAP(5-Lipoxygenase-activating protein) inhibitor with binding IC50 of 2.9 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.57mL

0.31mL

0.16mL

7.84mL

1.57mL

0.78mL

15.68mL

3.14mL

1.57mL
参考文献

[1]Stock NS, Bain G, et al. 5-Lipoxygenase-activating protein(FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl] -5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl] -2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor. J Med Chem. 2011 Dec 8;54(23):8013-29.

[2]Lorrain DS, Bain G, et al. Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. Eur J Pharmacol. 2010 Aug 25;640(1-3):211-8.