N3PT

产品说明书

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Chemical Structure| 13860-66-7 同义名 : N3-pyridyl thiamine
CAS号 : 13860-66-7
货号 : A996061
分子式 : C13H19Cl2N3OS
纯度 : 98%
分子量 : 336.281
MDL号 : MFCD26142554
存储条件：

Pure form Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 2 mg/mL(5.95 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 3PT is a potent and selective transketolase inhibitor, binds to the enzyme upon pyrophosphorylation with a dissociation constant (Kd) of 22 nM for the apoenzyme form of transketolase (Apo-TK), which lacks bound thiamine diphosphate[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.97mL

0.59mL

0.30mL

14.87mL

2.97mL

1.49mL

29.74mL

5.95mL

2.97mL
参考文献

[1]Thomas AA, et al. Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2206-10.