Mirogabalin besylate

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Chemical Structure| 1138245-21-2 同义名 : DS 5565 besylate
CAS号 : 1138245-21-2
货号 : A994372
分子式 : C18H25NO5S
纯度 : 98%
分子量 : 367.46
MDL号 : MFCD31631215
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(285.75 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Mirogabalin besylate is a ligand for the α2δ subunit of voltage-gated calcium channels, with Kds values of 13.5 nM, 22.7 nM, 27 nM and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1 and rat α2δ-2, respectively. Mirogabalin besylate has an affinity for the gabapentin binding site in rat cerebral cortical homogenate with an IC50 value of 16.0 nM. At a concentration of 50 μM, Mirogabalin besylate has no effect on other receptors, channels, transporters or enzymes[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.72mL

0.54mL

0.27mL

13.61mL

2.72mL

1.36mL

27.21mL

5.44mL

2.72mL
参考文献

[1]Domon Y, et al. Binding Characteristics and Analgesic Effects of Mirogabalin, a Novel Ligand for the α2δ Subunit of Voltage-Gated Calcium Channels. J Pharmacol Exp Ther. 2018 Jun;365(3):573-582.