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Tigogenin

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Chemical Structure| 77-60-1 同义名 : NSC 93754
CAS号 : 77-60-1
货号 : A993709
分子式 : C27H44O3
纯度 : 98%
分子量 : 416.637
MDL号 : MFCD00067287
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

无水乙醇: 12 mg/mL(28.8 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
描述 Tigogenin, a natural product isolated and purified from the herbs of Agave sisalana Perrine, induces apoptosis, associated with overexpression of COX-2 correlated with overproduction of endogenous PGE2, and may modulate differentiation of BMSCs to cause a lineage shift away from the adipocytes and toward the osteoblasts, which is at least mediated by inhibition of PPARgamma and via p38 MAPK pathway.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.40mL

0.48mL

0.24mL

12.00mL

2.40mL

1.20mL

24.00mL

4.80mL

2.40mL
参考文献

[1]Gu G, An L, et al. Efficient one-pot synthesis of tigogenin saponins and their antitumor activities. Carbohydr Res. 2014 Jan 13;383:21-6.

[2]Zhou H, Yang X, et al. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells. Mol Cell Endocrinol. 2007 May 30;270(1-2):17-22.