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Maslinic acid

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Chemical Structure| 4373-41-5 同义名 : 2α-Hydroxyoleanolic acid;Crategolic acid;2α-Hydroxyoleanoic Acid
CAS号 : 4373-41-5
货号 : A992541
分子式 : C30H48O4
纯度 : 98%
分子量 : 472.7
MDL号 : MFCD00049293
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(222.13 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Maslinic acid is a pentacyclic triterpenoid that is distributed in the peel of olives. Maslinic acid reduced liver weight and liver lipid accumulation and improved hepatocyte steatosis. In liver tissue, maslinic acid suppressed transcription factors involved in lipogenesis and increased adipose triglyceride lipase. In vitro, maslinic acid decreased lipogenesis by activating AMPK[3]. Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation. 20 μM Maslinic acid significantly suppresses TNF-α production and inhibits IL-1, IL-6, and COX-2 mRNA expression in RAW 264.7 cell. Maslinic acid (at 10 and 20 μM) significantly suppresses the DNA-binding activity of NF-κB p65 in LPS-induced RAW 264.7 cells. Furthermore, Maslinic Acid (200 mg/kg in the edema model or 100 mg/kg in the arthritis model) exerted anti-inflammatory and antiarthritis effects as shown by the suppression of paw edema, arthritis score, inflammatory cells, and destruction of synovium in knee joints[4]. Maslinic acid inhibit inflammatory effects induced by sPLA2-IIA(Secretory phospholipase A2-IIA is one of the key enzymes causing lipoprotein modification and vascular inflammation), including foam cells formation and PGE2 production[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02520739 Cardiovascular Diseases Phase 3 Unknown December 2016 Spain ... 展开 >> University Hospital Virgen de las Nieves Granada, Spain, 18012 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.12mL

0.42mL

0.21mL

10.58mL

2.12mL

1.06mL

21.16mL

4.23mL

2.12mL
参考文献

[1]Yu Y, Wang J, et al. Maslinic acid potentiates the antitumor activities of gemcitabine in vitro and in vivo by inhibiting NF-κB-mediated survival signaling pathways in human gallbladder cancer cells. Oncol Rep. 2015 Apr;33(4):1683-90.

[2]Chang T, Li X, et al. Maslinic acid activates mitochondria-dependent apoptotic pathway in cardiac carcinoma. Clin Invest Med. 2014 Aug 1;37(4):E217-24.

[3]Liou CJ, Dai YW, Wang CL, Fang LW, Huang WC. Maslinic acid protects against obesity-induced nonalcoholic fatty liver disease in mice through regulation of the Sirt1/AMPK signaling pathway. FASEB J. 2019;33(11):11791-11803

[4]Fukumitsu S, Villareal MO, Fujitsuka T, Aida K, Isoda H. Anti-inflammatory and anti-arthritic effects of pentacyclic triterpenoids maslinic acid through NF-κB inactivation. Mol Nutr Food Res. 2016;60(2):399-409

[5]Yap WH, Ooi BK, Ahmed N, Lim YM. Maslinic acid modulates secreted phospholipase A2-IIA (sPLA2-IIA)-mediated inflammatory effects in macrophage foam cells formation. J Biosci. 2018;43(2):277-285