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C-178

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Chemical Structure| 329198-87-0 同义名 : STING inhibitor C-178
CAS号 : 329198-87-0
货号 : A991151
分子式 : C17H10N2O5
纯度 : 99%+
分子量 : 322.272
MDL号 : MFCD01146392
存储条件:

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 40 mg/mL(124.12 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 C-178 functions as a powerful and specific covalent inhibitor targeting STING. It forms a bond with Cys91, effectively dampening STING reactions triggered by various authentic activators in mice but not in humans [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.10mL

0.62mL

0.31mL

15.51mL

3.10mL

1.55mL

31.03mL

6.21mL

3.10mL

参考文献

[1]Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273.