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Betulinaldehyde

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Chemical Structure| 13159-28-9 同义名 : Betulinic aldehyde;Betunal;Betulinic Aldehyde, Betulinaldehyde, Lup-20(29)-en-28-al, 3beta-hydroxy-, NSC 250423;NSC 250423;Betulinal
CAS号 : 13159-28-9
货号 : A989629
分子式 : C30H48O2
纯度 : 99%
分子量 : 440.7
MDL号 : MFCD12407180
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(40.84 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Betulinaldehyde (Betunal) belongs to pentacyclic triterpenoids and was reported to exhibit antimicrobial activities against bacteria and fungi, including S. aureus[3]. The MIC values of Betulinaldehyde against a reference strain of methicillin-resistant S. aureus (MRSA) (ATCC 43300) ranged from 64 µg/ml to 512 µg/ml[4]. It has also been reported to be a natural agonist of retinoic acid receptor-related orphan receptor γt (RORγt)[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.27mL

0.45mL

0.23mL

11.35mL

2.27mL

1.13mL

22.69mL

4.54mL

2.27mL
参考文献

[1]Ibrahim SR, Fouad MA, et al. Alnuheptanoid A: a new diarylheptanoid derivative from Alnus japonica. Nat Prod Res. 2014;28(20):1765-71.

[2]Chung PY, Chung LY, Navaratnam P. Identification, by gene expression profiling analysis, of novel gene targets in Staphylococcus aureus treated with betulinaldehyde. Res Microbiol. 2013 May;164(4):319-26.

[3]Chung PY, Chung LY, Navaratnam P. Identification, by gene expression profiling analysis, of novel gene targets in Staphylococcus aureus treated with betulinaldehyde. Res Microbiol. 2013;164(4):319-326

[4]Chung PY, Chung LY, Navaratnam P. Transcriptional profiles of the response of methicillin-resistant Staphylococcus aureus to pentacyclic triterpenoids. PLoS One. 2013;8(2):e56687

[5]Yang F, Zhang R, Ni D, et al. Discovery of betulinaldehyde as a natural RORγt agonist. Fitoterapia. 2019;137:104200.