产品说明书
GSK369796 2HCl
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同义名 : | GSK369796 (hydrochloride);GSK369796 Dihydrochloride;N-tert-butylisoquine;GSK369796 |
| CAS号 : | 1010411-21-8 | |
| 货号 : | A984981 | |
| 分子式 : | C20H24Cl3N3O | |
| 纯度 : | 99%+ | |
| 分子量 : | 428.783 | |
| MDL号 : | MFCD16627991 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(244.88 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 50 mg/mL(116.61 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | GSK369796 Dihydrochloride is an effective antimalarial. GSK369796 Dihydrochloride can also inhibit hERG potassium ion channel repolarization with an IC50 of 7.5±0.8 μM. In vitro, GSK369796 Dihydrochloride can inhibit the growth of Plasmodium falciparum strains 3D7c, HB3c and K1d, with IC50s of 11.2±2.2, 12.6±5.3 and 13.2±3.2 nM, respectively. In vivo, GSK369796 Dihydrochloride can inhibit the growth of Plasmodium berghei ANKA with ED50 and ED90 of 2.8 and 4.7 mg/kg, respectively[1]. GSK369796 has high anti-DENV activity in the DENV2 replicon expressing cells with EC50 value of 5.06 ± 0.86 μM. The infectivity assays revealed the EC50 value of 3.03 ± 0.35 μM. Moreover, GSK369796 also showed antiviral activity against the rapidly emerging Zika virus (ZIKV) with EC50 value of 2.57 ± 0.09 μM[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.33mL 0.47mL 0.23mL |
11.66mL 2.33mL 1.17mL |
23.32mL 4.66mL 2.33mL |
| 参考文献 |
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