MT-DADMe-ImmA

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Chemical Structure| 653592-04-2 同义名 : MTDIA;Methylthio-DADMe-Immucillin A
CAS号 : 653592-04-2
货号 : A984969
分子式 : C13H19N5OS
纯度 : 99%+
分子量 : 293.388
MDL号 : MFCD30738019
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(357.89 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 MT-DADMe-ImmA is an inhibitor of MTAP with a Ki value of 90 pM[1]. Treatment of cultured cells with MT-DADMe-ImmA and MTA inhibits MTAP, increases cellular MTA concentrations, reduces polyamines, and induces apoptosis in FaDu and Cal27 cells, but does not induce apoptosis in normal human fibroblast lines (CRL2522 and GM02037) or in MCF7 (a breast cancer cell line lacking the MTAP gene). Single use of MT-DADMe-ImmA does not induce apoptosis in any cell line, indicating that MTA acts as the active agent[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.41mL

0.68mL

0.34mL

17.04mL

3.41mL

1.70mL

34.08mL

6.82mL

3.41mL
参考文献

[1]Evans GB, et al. Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase. J Med Chem. 2005 Jul 14;48(14):4679-89.

[2]Basu I, et al. A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers. J Biol Chem. 2007 Jul 20;282(29):21477-86.