FK962

产品说明书

Print
Chemical Structure| 283167-06-6 同义名 : -
CAS号 : 283167-06-6
货号 : A979999
分子式 : C14H17FN2O2
纯度 : 99%+
分子量 : 264.295
MDL号 : MFCD09832545
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(945.91 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2 mg/mL(7.57 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 Somatostatin is a neuropeptide that plays an important role in learning and memory. The impairment of somatostatin-mediated neurotransmission is associated with dementia in Alzheimer's disease. FK962 is an anti-dementia compound that facilitates somatostatinergic nerve activity in hippocampal neurons. FK962 at a concentration of 10-7M significantly enhanced somatostatin release evoked by 50mM K+ stimulation from rat hippocampal slices (by 67% compared to the group without FK692). The co-treatment of 10-8M FK962 and somatostatin reversed somatostatin-induced inhibition of Ca2+ currents. Administration of FK962 (0.032-3.2mg/kg) prolonged the retention latency in scopolamine-treated rats with a bell-shaped dose-response curve with the maximal effect observed at 0.32mg/kg. The percentage of rats reaching criteria, which was another index of memory, was increased by FK962 treatment with a bell-shaped dose-dependency and the maximal effect was at 0.32mg/kg. FK962 treatment at 0.032 to 3.2mg/kg also restored the retention latency in nucleus basalis magnocellularis-lesioned rats and aged rats (26-27 months old)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.78mL

0.76mL

0.38mL

18.92mL

3.78mL

1.89mL

37.84mL

7.57mL

3.78mL
参考文献

[1]Tokita K, Inoue T, Yamazaki S, et al. FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats. Eur J Pharmacol. 2005;527(1-3):111-120. doi:10.1016/j.ejphar.2005.10.022