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Merestinib 2HCl

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Chemical Structure| 1206801-37-7 同义名 : LY2801653 dihydrochloride;Merestinib dihydrochloride
CAS号 : 1206801-37-7
货号 : A971365
分子式 : C30H24Cl2F2N6O3
纯度 : 98+%
分子量 : 625.453
MDL号 : -
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(167.88 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 LY2801653 dihydrochloride is a potent, orally bioavailable, small-molecule inhibitor of c-MET kinase (Ki= 2 nM).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.60mL

0.32mL

0.16mL

7.99mL

1.60mL

0.80mL

15.99mL

3.20mL

1.60mL
参考文献

[1]Barat S, Bozko P, et al. Targeting c-MET by LY2801653 for treatment of cholangiocarcinoma. Mol Carcinog. 2016 Dec;55(12):2037-2050.

[2]Yan SB, Peek VL, et al. LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models. Invest New Drugs. 2013 Aug;31(4):833-44.