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ITX3

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Chemical Structure| 347323-96-0 同义名 : -
CAS号 : 347323-96-0
货号 : A970865
分子式 : C22H17N3OS
纯度 : 98%+
分子量 : 371.455
MDL号 : MFCD02629172
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 2 mg/mL(5.38 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ITX3 emerges as a specific and non-toxic inhibitor of TrioN, the N-terminal GEF domain of the multi-domain Trio protein, displaying an IC50 value of 76 μM. This inhibitor is noted for its potential in research applications[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.46mL

2.69mL

1.35mL

26.92mL

5.38mL

2.69mL
参考文献

[1]Bouquier N, et al. A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem Biol. 2009 Jun 26;16(6):657-66.

[2]Yano T, et al. Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling. J Cell Biol. 2011 Apr 18;193(2):319-32.