[Pyr1]-Apelin-13

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Chemical Structure| 217082-60-5 同义名 : [pGlu1]-Apelin-13
CAS号 : 217082-60-5
货号 : A970543
分子式 : C69H108N22O16S
纯度 : 99%+
分子量 : 1533.8
MDL号 : MFCD01863147
存储条件：

Pure form Keep in dark place,Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 100 mg/mL(65.2 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 The APJ is an orphan G protein-coupled receptor that resembles the angiotensin receptor. Apelin-13 is an endogenous peptide ligand for human APJ receptor with an EC50 value of 0.37nM. In CHO cells expressing the APJ receptor, treatment with apelin-13 efficiently suppressed forskolin-stimulated cAMP production. (Glp1)-Apelin-13 is a pyroglutamylated form of apelin-13, with an EC50 value of 0.3nM for the APJ receptor[1]. Intracerebroventricular microinjection of (Glp1)-Apelin-13 (20nmol, dissolved in artificial cerebrospinal fluid) significantly reduced fever in LPS-treated rats during 3-9 hours after injection. Treatment with (Glp1)-Apelin-13 at the same dose also reduced the level of circulating tumor necrosis factor-α in LPS-challenged rats[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.65mL

0.13mL

0.07mL

3.26mL

0.65mL

0.33mL

6.52mL

1.30mL

0.65mL
参考文献

[1]Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, Kawamata Y, Fukusumi S, Hinuma S, Kitada C, Kurokawa T, Onda H, Fujino M. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998 Oct 20;251(2):471-6

[2]Hatzelmann T, Harden LM, Roth J, Gerstberger R. Antipyretic effect of central [Pyr1]apelin13 on LPS-induced fever in the rat. Regul Pept. 2013 Jun 10;184:6-13