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Rifamycin S

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Chemical Structure| 13553-79-2 同义名 : 1,4-Dideoxy-1,4-dihydro-1,4-dioxo-rifamycin
CAS号 : 13553-79-2
货号 : A969517
分子式 : C37H45NO12
纯度 : 98%
分子量 : 695.753
MDL号 : MFCD06198807
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(150.92 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Rifamycin S, a quinone antibiotic, targets Gram-positive bacteria (including MRSA). It represents the oxidized form of a reversible oxidation-reduction system involving two electrons. Rifamycin S generates reactive oxygen species (ROS) and impedes microsomal lipid peroxidation. It finds utility in the treatment of tuberculosis and leprosy [1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.44mL

0.29mL

0.14mL

7.19mL

1.44mL

0.72mL

14.37mL

2.87mL

1.44mL
参考文献

[1]Rao DN, et al. A comparative study of the redox-cycling of a quinone (rifamycin S) and a quinonimine (rifabutin) antibiotic by rat liver microsomes. Free Radic Biol Med. 1997;22(3):439-46.

[2]Kono Y. Oxygen Enhancement of bactericidal activity of rifamycin SV on Escherichia coli and aerobic oxidation of rifamycin SV to rifamycin S catalyzed by manganous ions: the role of superoxide. J Biochem. 1982 Jan;91(1):381-95.

[3]Huang H, et al. Rifamycin S and its geometric isomer produced by a newly found actinomycete, Micromonospora rifamycinica. Antonie Van Leeuwenhoek. 2009 Feb;95(2):143-8.