产品说明书
Paliperidone Palmitate
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同义名 : | - |
| CAS号 : | 199739-10-1 | |
| 货号 : | A967105 | |
| 分子式 : | C39H57FN4O4 | |
| 纯度 : | 98% | |
| 分子量 : | 664.893 | |
| MDL号 : | MFCD24386477 | |
| 存储条件： |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
无水乙醇: 2 mg/mL(3.01 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇 |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. Paliperidone palmitate shows efficacy against[2]. The drug proved to be efficacious in both acute psychotic symptoms treatment and long-term treatment. Its efficacy in patients with schizophrenia was similar and sometimes even better than the efficacy of other long-acting drugs, such as risperidone or olanzapine[3]. Once-monthly injectable paliperidone palmitate (PDP) has demonstrated comparable efficacy as 1st-generation long-acting injectable antipsychotics (LAIAs) in reducing disease severity and re-hospitalizations in schizophrenic patients. However, PDP leads to significantly less extrapyramidal symptoms than these older medications indicating a superior safety profile[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.50mL 0.30mL 0.15mL |
7.52mL 1.50mL 0.75mL |
15.04mL 3.01mL 1.50mL |
| 参考文献 |
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