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Kynurenine

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Chemical Structure| 2922-83-0 同义名 : L-犬尿氨酸水合物 ;3-anthraniloyl-Alanine;(S)-Kynurenine;CCRIS 4425;Kynurenine, L-;Kynurenine;L-KYN
CAS号 : 2922-83-0
货号 : A965360
分子式 : C10H12N2O3
纯度 : 99%+
分子量 : 208.214
MDL号 : MFCD00069912
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(57.63 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 20 mg/mL(96.06 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 L-Kynurenine and its breakdown products have a variety of biological functions, including vasodilatation during inflammation and modulation of the immune response. Some cancers increase the secretion of L-Kynurenine, which promotes tumour growth, and is also an AHR agonist that activates AHR-induced naive T cell polarisation to an anti-inflammatory Treg phenotype. At physiological concentrations, L-Kynurenine activates AHR signalling in H1L7.5c3 cells after 24 hours of action[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.80mL

0.96mL

0.48mL

24.01mL

4.80mL

2.40mL

48.03mL

9.61mL

4.80mL
参考文献

[1]Moyer BJ, et al. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24.

[2]Sakakibara K, et al. Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K(+) channels. J Pharmacol Sci. 2015 Sep;129(1):31-7.

[3]Nozaki K, et al. Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats. J Cereb Blood Flow Metab. 1992 May;12(3):400-7.