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描述 | GNE-317 is an optimized dual PI3K/mTOR inhibitor, which can cross the blood–brain barrier. Compared with the control group, a single oral dose of 50mg/kg GNE-317 significantly reduced pAkt, p4EBP1, and pS6 by 80%, 84%, and 92%, respectively, in the brain of normal mice at 1h post treatment. Oral administration of GNE-317 greatly inhibited GS2 brain tumor at 40mg/kg, daily for 6 weeks and U87 brain tumor at 40mg/kg, daily for 3 weeks, as well as prolonged survival of orthotopic GBM10 model[2]. |
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.41mL 0.48mL 0.24mL |
12.06mL 2.41mL 1.21mL |
24.13mL 4.83mL 2.41mL |
参考文献 |
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