产品说明书

NGI-1

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Chemical Structure| 790702-57-7 同义名 : ML414;N-linked Glycosylation Inhibitor 1
CAS号 : 790702-57-7
货号 : A956586
分子式 : C17H22N4O3S2
纯度 : 99%+
分子量 : 394.512
MDL号 : MFCD06358908
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(266.15 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 NGI-1, also known as ML414, is a potent oligosaccharyltransferase (OST) inhibitor that directly targets and blocks the function of the OST catalytic subunits STT3A and STT3B[1].NGI-1 effectively reduces viral infectivity without affecting cell viability. NGI-1 blocks N-linked glycosylation of EGFR in lung adenocarcinoma cells and results in altered cellular localisation of the EGFR[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.53mL

0.51mL

0.25mL

12.67mL

2.53mL

1.27mL

25.35mL

5.07mL

2.53mL
参考文献

[1]Zhu S, et al. Comprehensive Interactome Analysis Reveals that STT3B is Required for the N-Glycosylation of Lassa Virus Glycoprotein. J Virol. 2019 Sep 11. pii: JVI.01443-19.

[2]Lopez-Sambrooks C, et al. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol. 2016 Dec;12(12):1023-1030.