产品说明书
Vitamin U
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同义名 : | DL-蛋氨酸甲基氯化锍 ;VitaMin U;Cabagin-U;Smethylmethionine;Methylmethioninesulfonium Chloride |
| CAS号 : | 3493-12-7 | |
| 货号 : | A948177 | |
| 分子式 : | C6H14ClNO2S | |
| 纯度 : | 98% | |
| 分子量 : | 199.699 | |
| MDL号 : | MFCD00031700 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
H2O: 250 mg/mL(1251.88 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | DL-methionine methylsulfonium chloride is a naturally occurring methionine derivative. DL-methionine methylsulfonium chloride protects gastric mucosal from ethanol-induced damage. One milliliter of 1, 2, or 5% DL-cysteine (cysteine) or DL-methionine methylsulfonium chloride (MMSC) was instilled into the rat stomach 1, 24, and 48 h after giving ethanol (1 mL of 40% solution) by gavage. One hour following the administration of ethanol, gastric mucosal injury was seen in all the animals. Treatment with 2% cysteine or MMSC significantly (p less than 0.01) reduced the extent of this injury[1]. Gavage with 1% DL-cysteine or DL-methionine-S-methylsulfonium chloride at 1 mL/day for 2 weeks and 5 days protected against ulceration in 30% of the rats, and this protection extended to 80% of cases with 2% solutions. Similar gavage with 5% solutions protected all rats against ulceration without significantly influencing the basal H+ output [13.1 +/- 0.3 and 14.2 +/- 0.2 mumol for DL-cysteine and DL-methionine-S-methylsulfonium chloride, respectively, versus 15.1 +/- 0.4 mumol (mean +/- standard error of the mean; n = 10)]; that is, cytoprotection was achieved[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
5.01mL 1.00mL 0.50mL |
25.04mL 5.01mL 2.50mL |
50.08mL 10.02mL 5.01mL |
| 参考文献 |
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