DRB

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Chemical Structure| 53-85-0 同义名 : 5,6-Dichlorobenzimidazole riboside;Benzimidazole;NSC 401575;5,6-Dichlorobenzimidazole 1-beta-D-ribofuranoside
CAS号 : 53-85-0
货号 : A941159
分子式 : C12H12Cl2N2O4
纯度 : 99%+
分子量 : 319.141
MDL号 : MFCD00036785
存储条件：

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(329.01 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 7 mg/mL(21.93 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇

DMF: 100 mg/mL(313.34 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • CK2
描述 5,6-Dichlorobenzimidazole riboside (DRB) is a nucleoside analog that inhibits various carboxyl-terminal domain kinases, including casein kinase II and cell cycle-dependent kinases (CDK), and exhibits antitumor activity. It can also trigger apoptosis[1][2][3][4][5][6][7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.13mL

0.63mL

0.31mL

15.67mL

3.13mL

1.57mL

31.33mL

6.27mL

3.13mL
参考文献

[1]Zandomeni RO. Kinetics of inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole on calf thymus casein kinase II. Biochem J. 1989 Sep 1;262(2):469-73.

[2]Yankulov K, et al. The transcriptional elongation inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase. J Biol Chem. 1995 Oct 13;270(41):23922-5.

[3]Rickert P, et al. Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases. Oncogene. 1999 Jan 28;18(4):1093-102.

[4]Schang LM. Cyclin-dependent kinases as cellular targets for antiviral drugs. J Antimicrob Chemother. 2002 Dec;50(6):779-92.

[5]te Poele RH, et al. RNA synthesis block by 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells. Oncogene. 1999 Oct 14;18(42):5765-72.

[6]Kuo YH,et al. 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) induces apoptosis in breast cancer cells through inhibiting of Mcl-1 expression. Sci Rep. 2023 Aug 3;13(1):12621

[7]Kissman H M, et al. Synthesis and biological properties of certain 5, 6-dichlorobenzimidazole ribosides. Journal of the American Chemical Society, 1957, 79(5): 1185-1188