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meso-Dihydroguaiaretic acid

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Chemical Structure| 66322-34-7 同义名 : meso-DGA
CAS号 : 66322-34-7
货号 : A934783
分子式 : C20H26O4
纯度 : 98%
分子量 : 330.418
MDL号 : MFCD02752706
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(151.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Dihydroguaiaretic acid, a natural product isolated and purified from the aerial parts of Saururus chinensis. with antioxidative activity, inhibits the cyclooxygenase-2 (COX-2)-dependent phase of prostaglandin D2 (PGD2) generation in bone marrow-derived mast cells (BMMC) (IC50 9.8 μM), and shows an inhibitory effect against the complex formation of the fos-jun dimer and the DNA consensus sequence with an IC50 value of 0.21 micromol, suppresses leukemia, lung cancer and colon cancer in an in vitro bioassay.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.03mL

0.61mL

0.30mL

15.13mL

3.03mL

1.51mL

30.26mL

6.05mL

3.03mL
参考文献

[1]Nishiwaki H, Tabara Y, et al. Acute larvicidal activity against mosquitoes and oxygen consumption inhibitory activity of dihydroguaiaretic acid derivatives. J Agric Food Chem. 2015 Mar 11;63(9):2442-8.