Bevirimat

产品说明书

Print
Chemical Structure| 174022-42-5 同义名 : PA-457;MPC-4326;FH11327;3-O-(3',3'-Dimethylsuccinyl) Betulinic Acid;YK FH312
CAS号 : 174022-42-5
货号 : A933298
分子式 : C36H56O6
纯度 : 99%
分子量 : 584.83
MDL号 : MFCD00954243
存储条件：

Pure form Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(85.5 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Bevirimat is an anti-HIV drug derived from a betulinic acid-like compound, and is believed to inhibit HIV by a so-called maturation inhibition mechanism.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.71mL

0.34mL

0.17mL

8.55mL

1.71mL

0.85mL

17.10mL

3.42mL

1.71mL
参考文献

[1]Smith PF, Ogundele A, et al. Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection. Antimicrob Agents Chemother. 2007 Oct;51(10):3574-81.

[2]Salzwedel K, Martin DE, et al. Maturation inhibitors: a new therapeutic class targets the virus structure. AIDS Rev. 2007 Jul-Sep;9(3):162-72.