产品说明书
Levocetirizine 2HCl
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同义名 : | (R)-Cetirizine dihydrochloride;(R)-Cetirizine (hydrochloride);Xyzal;Xusal;UCB 28556;(-)-Cetirizine;Levocetirizine;(-)-Cetirizine Dihydrochloride;Xyzal Dihydrochloride;Levocetirizine dihydrochloride |
| CAS号 : | 130018-87-0 | |
| 货号 : | A930064 | |
| 分子式 : | C21H27Cl3N2O3 | |
| 纯度 : | 98% | |
| 分子量 : | 461.81 | |
| MDL号 : | MFCD07366507 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(227.37 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(216.54 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Levocetirizine 2HCl ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[3]. Levocetirizine has modest sedative effects with a risk ratio of 1.67 when compared with placebo[4]. Montelukast, levocetirizine and their combination is equally effective in controlling symptoms, of allergic rhinitis[5]. Male Sprague Dawley rats received either levocetirizine (1 mg/kg/day, orally) or the vehicle of the drug (2 ml/kg/day, orally) for 1 week before a single IP injection of LPS (7.5 mg/kg). Levocetirizine attenuated lung edema and mitigated the increases in BALF (bronchoalveolar lavage fluid) protein levels, LDH (lactate dehydrogenase) activity, and lung leukocyte recruitment in LPS-challenged rats. Additionally, TNF-α protein levels in BALF and lung tissue were diminished by levocetirizine administration. Levocetirizine may offer protection against lung tissue damage and inflammation in LPS-challenged rats[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.17mL 0.43mL 0.22mL |
10.83mL 2.17mL 1.08mL |
21.65mL 4.33mL 2.17mL |
| 参考文献 |
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