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Ammonium glycyrrhizinate

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Chemical Structure| 53956-04-0 同义名 : 甘草酸铵盐;甘草酸单胺;甘草酸单铵盐 ;Monoammonium glycyrrhizinate;Glycyrrhizic acid ammonium salt;Monoammonium glycyrrhizate;Monoammonium 18β-glycyrrhizinate;Magnasweet;Glycyrrhizin monoammonium salt;Glycyrrhizin ammonium salt;Glycyron ammonium salt;Glycymin;18β-Glycyrrhizic acid monoammonium salt;NSC 35348;NSC 2800;Glycyrrhizinate;Glycyrrhizin;Glycyrram;Glycamil;Ammonium glycyrrhizate
CAS号 : 53956-04-0
货号 : A919245
分子式 : C42H65NO16
纯度 : 98%
分子量 : 839.963
MDL号 : MFCD00167400
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(125.01 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Ammonium glycyrrhizinate, a natural constituent of the licorice root that inhibits growth and cytopathology of several unrelated DNA and RNA viruses. A short-repeated treatment with ammonium glycyrrhizinate was able to attenuate neuropathic hyperalgesia in streptozotocin-induced diabetic mice. Ammonium glycyrrhizinate could ameliorate diabetic peripheral neuropathy, counteracting both in vitro and in vivo effects induced by high glucose, and might represent a complementary medicine for the clinical management of diabetic peripheral neuropathy[3]. Ammonium glycyrrhizinate (50, 100, 200 mg/kg, p.o.) is effective in controlling serum lipid profile and cardiac complications in experimentally induced cardiomyopathy in animals[4]. CAG (compound ammonium glycyrrhizin) as a potential therapeutic agent to counteract LPS/AC(lipopolysaccharide/amoxicillin clavulanate potassium)-induced liver injury[5]. LPS/ENR(Lipopolysaccharide/enrofloxacin)-treated hepatocytes were damaged via apoptotic signaling pathways and CAG prevented LPS/ENR-induced hepatocyte injury[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.19mL

0.24mL

0.12mL

5.95mL

1.19mL

0.60mL

11.91mL

2.38mL

1.19mL
参考文献

[1]Marianecci C, Rinaldi F, et al. Ammonium glycyrrhizinate-loaded niosomes as a potential nanotherapeutic system for anti-inflammatory activity in murine models. Int J Nanomedicine. 2014 Jan 24;9:635-51.

[2]Oh HM, Lee S, et al. Ammonium glycyrrhizinate protects gastric epithelial cells from hydrogen peroxide-induced cell death. Exp Biol Med(Maywood). 2009 Mar;234(3):263-77.

[3]Ciarlo L, Marzoli F, Minosi P, Matarrese P, Pieretti S. Ammonium Glycyrrhizinate Prevents Apoptosis and Mitochondrial Dysfunction Induced by High Glucose in SH-SY5Y Cell Line and Counteracts Neuropathic Pain in Streptozotocin-Induced Diabetic Mice. Biomedicines. 2021 May 26;9(6):608

[4]Garg M, Singhal T, Sharma H. Cardioprotective effect of ammonium glycyrrhizinate against doxorubicin-induced cardiomyopathy in experimental animals. Indian J Pharmacol. 2014 Sep-Oct;46(5):527-30

[5]Yu Z, Wu F, Tian J, Guo X, An R, Guo Y. Ammonium glycyrrhizin counteracts liver injury caused by lipopolysaccharide/amoxicillin-clavulanate potassium. Oncotarget. 2017 May 30;8(57):96837-96851

[6]Guo X, Li W, An R, Huang M, Yu Z. Composite ammonium glycyrrhizin has hepatoprotective effects in chicken hepatocytes with lipopolysaccharide/enrofloxacin-induced injury. Exp Ther Med. 2020 Nov;20(5):52