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CA-074 methyl ester

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Chemical Structure| 147859-80-1 同义名 : CA-074Me;Cathepsin B Inhibitor IV
CAS号 : 147859-80-1
货号 : A917874
分子式 : C19H31N3O6
纯度 : 95%
分子量 : 397.466
MDL号 : MFCD03452890
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(264.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CA-074 is a selective cathepsin B inhibitor with Ki value about 2-5nM for purified rat cathepsin B, 10000~30000 times greater than the Ki values for cathepsin H and L. Intraperitoneal injection of 8mg CA-074 into rats potently inhibited cathepsin B in vivo[3]. Intraperitoneal administration of 50mg/kg CA-074 reduced metastasis in mice-bearing 4T1.2 tumors[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.52mL

0.50mL

0.25mL

12.58mL

2.52mL

1.26mL

25.16mL

5.03mL

2.52mL
参考文献

[1]Towatari T, Nikawa T, et al. Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo. FEBS Lett. 1991 Mar 25;280(2):311-5.

[2]Withana NP, Blum G, et al. Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res. 2012 Mar 1;72(5):1199-209.

[3]Towatari T, Nikawa T, Murata M, Yokoo C, Tamai M, Hanada K, Katunuma N. Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo. FEBS Lett. 1991 Mar 25;280(2):311-5. doi: 10.1016/0014-5793(91)80319-x. PMID: 2013329.

[4]Withana NP, Blum G, Sameni M, Slaney C, Anbalagan A, Olive MB, Bidwell BN, Edgington L, Wang L, Moin K, Sloane BF, Anderson RL, Bogyo MS, Parker BS. Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res. 2012 Mar 1;72(5):1199-209. doi: 10.1158/0008-5472.CAN-11-2759. Epub 2012 Jan 19. PMID: 22266111; PMCID: PMC3538126.