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AP-III-a4 HCl

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Chemical Structure| 2070014-95-6 同义名 : ENOblock hydrochloride;AP-III-a4 hydrochloride
CAS号 : 2070014-95-6
货号 : A917274
分子式 : C31H44ClFN8O3
纯度 : 98+%
分子量 : 631.184
MDL号 : N/A
存储条件：

粉末

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(79.22 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 12 mg/mL(19.01 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 AP-III-a4 hydrochloride is a small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM) and inhibit cancer cell metastasis in vivo.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.58mL

0.32mL

0.16mL

7.92mL

1.58mL

0.79mL

15.84mL

3.17mL

1.58mL
参考文献

[1]Jung DW, Kim WH, et al. A unique small molecule inhibitor of enolase clarifies its role in fundamental biological processes. ACS Chem Biol. 2013;8(6):1271-82.