HA-100

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Chemical Structure| 84468-24-6 同义名 : 1-(5-异喹啉磺酰基)哌嗪
CAS号 : 84468-24-6
货号 : A914568
分子式 : C13H15N3O2S
纯度 : 97%
分子量 : 277.342
MDL号 : MFCD00209852
存储条件:

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 145 mg/mL(522.82 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 HA-100 is recognized as a strong inhibitor of various protein kinases, exhibiting IC50 values of 4 μM for PKG, 8 μM for PKA, 12 μM for PKC, and 240 μM for MLC-kinase. Additionally, HA-100 is employed as an inhibitor of ROCK[1][2]. HA-100 acts as a competitive inhibitor of MLC-kinase and PKC in the presence of ATP, with inhibition constants (Kis) of 61 μM and 6.5 μM, respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.61mL

0.72mL

0.36mL

18.03mL

3.61mL

1.80mL

36.06mL

7.21mL

3.61mL

参考文献

[1]Hagiwara M, et al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12.

[2]Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557.