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Myricetrin

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Chemical Structure| 17912-87-7 同义名 : Myricitrin;Myricitroside;NSC 19803;Myricitrine
CAS号 : 17912-87-7
货号 : A913927
分子式 : C21H20O12
纯度 : 96%
分子量 : 464.376
MDL号 : MFCD00016930
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(226.11 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • PKCα
描述 Myricitrin, isolated from Daebong persimmon peel, is a major antioxidant flavonoid. Myricitrin had the strongest antioxidant activities by ferric ion reducing antioxidant power and α,α-diphenyl-2-picrylhydrazyl radical scavenging assays[3]. Myricitrin decreased the level of total serum cholesterol and the role of aortic atherosclerosis in hypercholesterolemic rats[4]. Myricitrin had the anti-diabetic and hepatoprotective effects on the aged mice induced by D-galactose[5]. Myricitrin ameliorated neuroinflammation and improved memory in rats with CLP(cecal ligation and puncture)-induced sepsis by regulating the NLRP3/Bax/Bcl signalling pathway[6]. Myricitrin blocks activation of protects NF-κB and MAPK signaling pathways to nigrostiatum neuron from injury in LPS-stimulated mice and is beneficial to treatment nigrostriatum inflammation of PD[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.15mL

0.43mL

0.22mL

10.77mL

2.15mL

1.08mL

21.53mL

4.31mL

2.15mL
参考文献

[1]Meotti FC, Fachinetto R, et al. Antinociceptive action of myricitrin: involvement of the K+ and Ca2+ channels. Eur J Pharmacol. 2007 Jul 19;567(3):198-205.

[2]Meotti FC, Luiz AP, et al. Analysis of the antinociceptive effect of the flavonoid myricitrin: evidence for a role of the L-arginine-nitric oxide and protein kinase C pathways. J Pharmacol Exp Ther. 2006 Feb;316(2):789-96.

[3]Hwang IW, Chung SK. Isolation and Identification of Myricitrin, an Antioxidant Flavonoid, from Daebong Persimmon Peel. Prev Nutr Food Sci. 2018 Dec;23(4):341-346

[4]Gao J, Liu C, Zhang H, Sun Z, Wang R. Myricitrin exhibits anti-atherosclerotic and anti-hyperlipidemic effects in diet-induced hypercholesterolemic rats. AMB Express. 2019 Dec 21;9(1):204

[5]Omidi M, Ahangarpour A, Khorsandi L, Ramezani-AliAkbari F. The antidiabetic and hepatoprotective effects of myricitrin on aged mice with D-galactose. Gastroenterol Hepatol Bed Bench. 2020 Summer;13(3):247-253

[6]Gong J, Luo S, Zhao S, Yin S, Li X, Mou T. Myricitrin attenuates memory impairment in a rat model of sepsis-associated encephalopathy via the NLRP3/Bax/Bcl pathway. Folia Neuropathol. 2019;57(4):327-334

[7]Yang YL, Liu M, Cheng X, Li WH, Zhang SS, Wang YH, Du GH. Myricitrin blocks activation of NF-κB and MAPK signaling pathways to protect nigrostriatum neuron in LPS-stimulated mice. J Neuroimmunol. 2019 Dec 15;337:577049