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GSK2807 Trifluoroacetate

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Chemical Structure| 2245255-66-5 同义名 : -
CAS号 : 2245255-66-5
货号 : A912563
分子式 : C21H33F3N8O7
纯度 : 99%+
分子量 : 566.531
MDL号 : MFCD31715435
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(185.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(88.26 mM)
动物实验配方：
生物活性
描述 SMYD3 is a lysine methyltransferase implicated as an oncogene in human malignancies, which is found to be overexpressed in colorectal, breast, prostate, and hepatocellular tumors. Methylation of its target, MEKK2, is important for regulation of the MEK/ERK pathway. GSK2807 Trifluoroacetate is the trifluoroacetate form of GSK2807. GSK2807 is a potent and selective, SAM-competitive inhibitor of SMYD3 with Ki value of 14nM, with selectivity to SMYD3 over a panel of protein methyltransferases including SMYD2, PRMT1, PRMT4, PRMT5, NSD2, NSD3, DOT1L, G9a and ASH1L. GSK2807 could form a dead-end ternary complex with SMYD3 and MEKK2.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.77mL

0.35mL

0.18mL

8.83mL

1.77mL

0.88mL

17.65mL

3.53mL

1.77mL