LDN-193189 dihydrochloride

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Chemical Structure| 1435934-00-1 同义名 : DM-3189 dihydrochloride;LDN-193189 (hydrochloride);DM-3189;DM-3189 2HCl;LDN-193189 2HCl
CAS号 : 1435934-00-1
货号 : A911398
分子式 : C25H24Cl2N6
纯度 : 99%
分子量 : 479.404
MDL号 : MFCD23098917
存储条件：

Pure form Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 9 mg/mL(18.77 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 10 mg/mL(20.86 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • ALK1

    ALK1, IC50:0.8 nM

  • ALK2

    ALK2, IC50:0.8 nM

  • ALK6

    ALK6, IC50:16.7 nM

  • ALK3

    ALK3, IC50:5.3 nM
描述 LDN193189 potently inhibits BMP4-mediated Smad1, Smad5 and Smad8 activation with IC50 of 5 nM, and efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively. Furthermore, LDN193189 also shows the inhibitory effect on the transcriptional activity induced by either constitutively active ALK2 or ALK2 mutant proteins. A recent study shows that LDN-193189 blocks the production of reactive oxygen species induced by oxidized LDL during atherogenesis in human aortic endothelial cells.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.09mL

0.42mL

0.21mL

10.43mL

2.09mL

1.04mL

20.86mL

4.17mL

2.09mL