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HJC0152

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Chemical Structure| 1420290-99-8 同义名 : HJC0152 (hydrochloride)
CAS号 : 1420290-99-8
货号 : A911245
分子式 : C15H14Cl3N3O4
纯度 : 98%
分子量 : 406.648
MDL号 : MFCD29770804
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 1 mg/mL(2.46 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • STAT3
描述 HJC0152 markedly suppresses cell growth and triggers apoptosis, which is evident through changes in cell shape at concentrations of 1, 5, and 10 μM. Studies indicate that a 10 μM concentration of HJC0152 reduces STAT3 promoter activity by about 32% in MDA-MB-231 cells, and a higher concentration of 20 μM leads to a further reduction in STAT3 promoter activity by 62% compared to the control group. Additionally, the overall levels of STAT3 diminish following HJC0152 treatment. The compound also promotes the activation of cleaved caspase-3 and the downregulation of cyclin D1 in MDA-MB-231 cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.46mL

0.49mL

0.25mL

12.30mL

2.46mL

1.23mL

24.59mL

4.92mL

2.46mL
参考文献

[1]Chen H, et al. Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents. ACS Med Chem Lett. 2013 Feb 14;4(2):180-185.