PTC-209

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Chemical Structure| 315704-66-6 同义名 : -
CAS号 : 315704-66-6
货号 : A910946
分子式 : C17H13Br2N5OS
纯度 : 99%+
分子量 : 495.191
MDL号 : MFCD02110649
存储条件：

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(60.58 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 PTC-209 is a specific inhibitor for BMI-1 with IC50 of 0.5 μM in in both GEMS reporter and ELISA assays.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.02mL

0.40mL

0.20mL

10.10mL

2.02mL

1.01mL

20.19mL

4.04mL

2.02mL
参考文献

[1]Shahi MH, York D, et al. BMI1 is expressed in canine osteosarcoma and contributes to cell growth and chemotherapy resistance. PLoS One. 2015 Jun 25;10(6):e0131006.

[2]Mayr C, Wagner A, et al. The BMI1 inhibitor PTC-209 is a potential compound to halt cellular growth in biliary tract cancer cells. Oncotarget. 2016 Jan 5;7(1):745-58.