Triclabendazole sulfoxide
产品说明书
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同义名 : | TCBZ-SO |
| CAS号 : | 100648-13-3 | |
| 货号 : | A906988 | |
| 分子式 : | C14H9Cl3N2O2S | |
| 纯度 : | 97% | |
| 分子量 : | 375.658 | |
| MDL号 : | MFCD19441813 | |
| 存储条件： |
Pure form Sealed in dry,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Triclabendazole sulfoxide (TCBZSO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. TCBZSO is ABCG2 inhibitor. TCBZSO administration also inhibited nitrofurantoin Abcg2-mediated secretion into milk by more than 2-fold and increased plasma levels of the sulfonamide sulfasalazine by more than 1.5-fold in mice[1]. CYP1A2, CYP2C8, CYP2C9 were inhibited by triclabendazole sulfoxide with IC50 of 4.19 µM, 8.95 µM, and 1.95 µM, respectively. CYP2C19 was inhibited by triclabendazole and triclabendazole sulfoxide with IC50 of 0.25 and 0.22 µM[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.66mL 0.53mL 0.27mL |
13.31mL 2.66mL 1.33mL |
26.62mL 5.32mL 2.66mL |
| 参考文献 |
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