产品说明书
Piroctone olamine
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同义名 : | 羟吡酮 ;Piroctone ethanolamine |
| CAS号 : | 68890-66-4 | |
| 货号 : | A903889 | |
| 分子式 : | C16H30N2O3 | |
| 纯度 : | 97% | |
| 分子量 : | 298.421 | |
| MDL号 : | MFCD01690792 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 10 mg/mL(33.51 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 50 mg/mL(167.55 mM)，配合低频超声，并调节pH至9 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Piroctone olamine is a pyridine derivate. It is known to have a fungicidal effect. For the C/P (climbazole/piroctone olamine) cream, the MICs were 0.625, 5, 0.625, and 2.5 mg/ml for Malassezia restricta, M. globosa, M. sympodialis, and M. slooffiae, respectively. Based on the reduced casual sebum level and extent of erythema, the antifungal activity of C/P cream against Malassezia species seems useful for the treatment of mild to moderate SD(Seborrheic dermatitis)[1]. Piroctone olamine (PO) is an ethanolamine salt of the hydroxamic acid derivative Piroctone. All Candida strains show low minimum inhibitory concentrations (MICs) for Piroctone olamine (0.125-0.5 μg/mL) and Amphotericin B (AMB) (0.03-1 μg/mL) [2]. A comparable anti-fungal effectiveness for 0.5% piroctone olamine plus 0.45% climbazole and 1% zinc pyrithione, respectively. The shampoo formulation with 0.5% piroctone olamine and 0.45% climbazole effectively reduces the amount of dandruff and, at the same time, provides hair conditioning advantages[3]. Moreover, Piroctone olamine demonstrated a major apoptotic activity in various human and murine myeloma and lymphoma cell lines, as well as in human primary cells. In vivo, tumor growth, as well as overall survival, was significantly reduced in mice treated with PO as compared to untreated mice[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.35mL 0.67mL 0.34mL |
16.75mL 3.35mL 1.68mL |
33.51mL 6.70mL 3.35mL |
| 参考文献 |
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