产品说明书

Telotristat etiprate

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Chemical Structure| 1137608-69-5 同义名 : LX1606 Hippurate;LX 1032 hippurate
CAS号 : 1137608-69-5
货号 : A902254
分子式 : C36H35ClF3N7O6
纯度 : 99%+
分子量 : 754.155
MDL号 : MFCD22741520
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 190 mg/mL(251.94 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Hydroxylase
描述 Telotristat Etiprate an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.33mL

0.27mL

0.13mL

6.63mL

1.33mL

0.66mL

13.26mL

2.65mL

1.33mL
参考文献

[1]Pavel M, Horsch D, et al. Telotristat etiprate for carcinoid syndrome: a single-arm, multicenter trial. J Clin Endocrinol Metab. 2015 Apr;100(4):1511-9.

[2]Kulke MH, O'Dorisio T, et al. Telotristat etiprate, a novel serotonin synthesis inhibitor, in patients with carcinoid syndrome and diarrhea not adequately controlled by octreotide. Endocr Relat Cancer. 2014 Oct;21(5):705-14.